|
KMID : 0881720210360040353
|
|
Journal of Food Hygiene and Safety
2021 Volume.36 No. 4 p.353 ~ p.362
|
|
|
Antioxidant and Anti-Cholesterol Activities of Standardized Ecklonia stolonifera Extract
|
|
Han Xionggao
Kim Woo-Hyeok
Choi Sun-Il
Men Xiao
Lee Se-Jeong
Jin Hee-Gu
Oh Hyun-Ji
Kang Da-Hye
Kim Hyung-Bin
Lee Boo-Yong
Lee Ok-Hwan
|
|
|
Abstract
|
|
|
|
Ecklonia stolonifera, which belongs to the family Laminariaceae, is an edible perennial brown marine alga that is widely distributed, and is rich in polyphenols, including dieckol. Here, we investigated the radical scavenging activities of E. stolonifera extract (ESE) using various in vitro models. We further evaluated the effect of ESE on the cholesterol secretion inhibition activity in HepG2 cells, as well as the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase activity. Our results showed that the total phenol, total flavonoid, and dieckol contents of ESE were 9.64±0.04 mg GAE/g, 2.72±0.08 mg RE/g and 27.42±0.66 mg/g, respectively. The antioxidant activity of ESE increased in a dose-dependent manner. In addition, the ESE inhibited cholesterol secretion from HepG2 cells with anti-HMG-CoA reductase activity. These results suggested that ESE possesses antioxidant and anti-cholesterol activities, and can therefore be used as a preclinical bioresource for development of health functional foods.
|
|
|
KEYWORD
|
|
|
Ecklonia stolonifera, Antioxidant activity, HMG-CoA reductase, Anti-cholesterol activity, Dieckol
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|